144 – The Anti-Cancer Properties of IP-6 – My Interview with Dr. Abulkalam Shamsuddin

IP-6 inhibits cancer cell growth

Dr. Abdulkalam ShamsuddinCancer SupportInositol hexaphosphate (IP(6)) is a naturally occurring carbohydrate, abundantly present in many plant sources and in certain high-fiber diets, such as cereals and legumes. In addition to being found in plants, IP(6) is contained in almost all mammalian cells, although in much smaller amounts, where it is important in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation. For a long time IP(6) has been recognized as a natural antioxidant. Recently IP(6) has received much attention for its role in cancer prevention and control of experimental tumor growth, progression, and metastasis. In addition, IP(6) possesses other significant benefits for human health, such as the ability to enhance immune system, prevent pathological calcification and kidney stone formation, lower elevated serum cholesterol, and reduce pathological platelet activity. IP(6) is rapidly taken up into cells which further affect signal pathways resulting in cell cycle arrest. A striking anticancer Cancer Cellsaction of IP(6) was demonstrated in different experimental models. In addition to reducing cell proliferation, IP(6) also induces differentiation of malignant cells. Enhanced immunity and antioxidant properties also contribute to tumor cell destruction. Preliminary studies in humans show that IP(6) and inositol, the precursor molecule of IP(6), appear to enhance the anticancer effect of conventional chemotherapy, control cancer metastases, and improve quality of life. Because it is abundantly present in regular diet, efficiently absorbed from the gastrointestinal tract, and safe, IP(6) + inositol holds great promise in our strategies for cancer prevention and therapy. Excerpt (Abstract: Protection against cancer by dietary IP6 and inositol. Nutr Cancer. 2006;55(2):109-25.)

About Dr. Abulkalam Shamsuddin M.B.B.S., Ph.D.
Dr Shamsuddin graduated Dhaka Medical College, University of Dhaka in 1972. Following Internship in Massachusetts and Residency training in pathology in Maryland, he was certified by the American Board of Pathology in 1977. In 1980, he received Ph.D. degree from the University of Maryland for his work on colon carcinogenesis. He joined the faculty of the University of Maryland as an Instructor in 1977, and rose through the ranks of Assistant Professor and Associate Professor to become a full Professor in 1988. For his excellence in teaching he received the Best Teacher award from the medical students many times, including the coveted “Golden Apple Award” by the American Medical Students’ Association in 1999.

Research Interests:
IP-6 Cancer FighterDr. Shamsuddin has been studying the process of cancer formation and the prevention of cancer since 1975. His research in the steps of colon cancer formation resulted in the development of a very simple and accurate screening test for colon cancer. This rather inexpensive test detects cancers at a very early stage, and even before they have formed; in other words, it can also detect precancerous polyps and other precancerous lesions and conditions. The test has been in use in China since the early 1990’s often referred to as “Shams’ Test.” He further discovered that the colon cancer marker Gal-GalNAc is a common cancer marker expressed through a similar “field-effect” phenomenon; thus forming the basis for a general cancer screening test such as for cancer of the lungs and breast, and possibly prostate and uterine cervix.

In mid 1985, Dr. Shamsuddin started his pioneering experiments on the anti-cancer property of inositol and inositol hexaphosphate (IP-6) – natural constituents of cereals and legumes such as rice, corn, beans etc. For the next two decades, he has reconfirmed and expanded his groundbreaking studies to show the efficacy of IP-6 and inositol against different cancers in various experimental models. Dr. Shamsuddin’s book on this “IP6: Nature’s Revolutionary Cancer Fighter” by Kensington Publishing Corporation, New York, 1998, is written for the general public. Aside from these Dr. Shamsuddin has contributed numerous book-chapters and published over 200 scientific papers.

{ 11 comments… read them below or add one }

1 Stephanie Anthony November 9, 2018 at 6:27 pm

How would I email Dr shamsuddin. I have been diagnosed with cancer and I bought IP-6 but I don’t know how much to take


2 Steve Lankford November 9, 2018 at 6:43 pm

I’m sorry, but I don’t have any contact information for Dr. Shamsuddin. Start by following label directions on the IP6 package. Take the highest recommend amount. Then you could contact the company. They may have some specific guidance or can guide you to appropriate information. You could inquire if Dr. Shamsuddin is available. They may know. You might find a copy of his book on IP6. It’s dated but still valuable.


3 Chris Maxwell September 16, 2018 at 3:31 pm

I need to find out about dosage, with cancer I was told we need alot more then the dosage on the bottle, maybe the powder would be better since we would need such a high dose, please email me back as soon as possible thank you


4 Steve Lankford September 16, 2018 at 3:48 pm

You need to consult a health care professional. I am not a doctor.


5 FATMA ZOHRA DOUDOU September 12, 2018 at 6:39 am


IS ABOUT MY MOTHER 83 YEARS WHITH HIGH GRADE GLIOBLASTOMA will the products IP6 helps her to shrink tumor if possible how many dosage she is in advanced state. please help if you know other supplements or herbs because i want to give her indiburine 97% but she is very very tired in bad cannot talk or move her hand.

best regards


6 Steve Lankford September 16, 2018 at 3:49 pm

You need to consult a health care professional. I am not a doctor.


7 David September 16, 2017 at 9:52 am

Have an infection was given antibiotics for it. Could I use ip6 and inositol when using my antibiotics??


8 Steve Lankford September 16, 2017 at 4:49 pm

Don’t know. I think you would be OK, but check with your Dr.


9 Cheryl Delyon June 2, 2016 at 12:56 pm

Your product IP6 powder cured my best friend of stage 4 breast cancer that metastasized into her nodes. She was given 3 to 6 months with no chemo or radiation only hormone depletion. I researched and found your product we then went and spoke to a nutritionist. She is on 1 scoop of powder 2 times per day on empty stomach and in the beginning was on 3 times per day. It had been almost 2 years and breast cancer is completely gone and bone tumors have shrunk considerably. I now take this and so do all my friends and relatives and have been for a year and a half. Its has cured prostate cancer, diabetes, aches from arthritis. I cannot thank you enough or speak highly enough of your product.


10 Goldie April 20, 2016 at 2:01 pm

Great interview! Thx.
What is the difference between Inositol and Inositol hexaphosphate (IP(6)?


11 Steve Lankford April 23, 2016 at 4:52 pm

Please search the internet for an answer.


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