IP-6 inhibits cancer cell growth

Dr. Abdulkalam ShamsuddinCancer SupportInositol hexaphosphate (IP(6)) is a naturally occurring carbohydrate, abundantly present in many plant sources and in certain high-fiber diets, such as cereals and legumes. In addition to being found in plants, IP(6) is contained in almost all mammalian cells, although in much smaller amounts, where it is important in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation. For a long time IP(6) has been recognized as a natural antioxidant. Recently IP(6) has received much attention for its role in cancer prevention and control of experimental tumor growth, progression, and metastasis. In addition, IP(6) possesses other significant benefits for human health, such as the ability to enhance immune system, prevent pathological calcification and kidney stone formation, lower elevated serum cholesterol, and reduce pathological platelet activity. IP(6) is rapidly taken up into cells which further affect signal pathways resulting in cell cycle arrest. A striking anticancer Cancer Cellsaction of IP(6) was demonstrated in different experimental models. In addition to reducing cell proliferation, IP(6) also induces differentiation of malignant cells. Enhanced immunity and antioxidant properties also contribute to tumor cell destruction. Preliminary studies in humans show that IP(6) and inositol, the precursor molecule of IP(6), appear to enhance the anticancer effect of conventional chemotherapy, control cancer metastases, and improve quality of life. Because it is abundantly present in regular diet, efficiently absorbed from the gastrointestinal tract, and safe, IP(6) + inositol holds great promise in our strategies for cancer prevention and therapy. Excerpt (Abstract: Protection against cancer by dietary IP6 and inositol. Nutr Cancer. 2006;55(2):109-25.)

About Dr. Abulkalam Shamsuddin M.B.B.S., Ph.D.
Dr Shamsuddin graduated Dhaka Medical College, University of Dhaka in 1972. Following Internship in Massachusetts and Residency training in pathology in Maryland, he was certified by the American Board of Pathology in 1977. In 1980, he received Ph.D. degree from the University of Maryland for his work on colon carcinogenesis. He joined the faculty of the University of Maryland as an Instructor in 1977, and rose through the ranks of Assistant Professor and Associate Professor to become a full Professor in 1988. For his excellence in teaching he received the Best Teacher award from the medical students many times, including the coveted “Golden Apple Award” by the American Medical Students’ Association in 1999.

Research Interests:
IP-6 Cancer FighterDr. Shamsuddin has been studying the process of cancer formation and the prevention of cancer since 1975. His research in the steps of colon cancer formation resulted in the development of a very simple and accurate screening test for colon cancer. This rather inexpensive test detects cancers at a very early stage, and even before they have formed; in other words, it can also detect precancerous polyps and other precancerous lesions and conditions. The test has been in use in China since the early 1990’s often referred to as “Shams’ Test.” He further discovered that the colon cancer marker Gal-GalNAc is a common cancer marker expressed through a similar “field-effect” phenomenon; thus forming the basis for a general cancer screening test such as for cancer of the lungs and breast, and possibly prostate and uterine cervix.

In mid 1985, Dr. Shamsuddin started his pioneering experiments on the anti-cancer property of inositol and inositol hexaphosphate (IP-6) – natural constituents of cereals and legumes such as rice, corn, beans etc. For the next two decades, he has reconfirmed and expanded his groundbreaking studies to show the efficacy of IP-6 and inositol against different cancers in various experimental models. Dr. Shamsuddin’s book on this “IP6: Nature’s Revolutionary Cancer Fighter” by Kensington Publishing Corporation, New York, 1998, is written for the general public. Aside from these Dr. Shamsuddin has contributed numerous book-chapters and published over 200 scientific papers.



Dr. Christopher Mohr is an expert in sports nutrition, weight loss and essential fatty acids.

Dr. Christopher MohrOmega-3If you are a regular listener to, you know I think omega-3 fatty acids are perhaps the most important single nutrient you can take. Especially marine based omega-3 (as opposed to plant based omega-3). Second only maybe to a multi-vitamin supplement. If you listen to our collection of interviews on fish oil omega-3 you will understand why this nutrient is foundational to your health. My personal opinion is that if you don’t increase omega-3 AND reduce omega-6 in your diet and if your omega-3 is deficient, you will be challenged to be fully healthy. The deficiency of omega-3 is epidemic and is a major factor in every inflammatory condition. Again, this is my personal opinion. Click on the Omega-3 image in the upper right to see all of our interviews on omega-3.

In this interview with Dr. Christopher Mohr, we will discuss the challenges of weight loss and the importance of omega-3. Dr. Mohr is a recognized expert in weight loss, sports nutrition and training, fitness and exercise, inflammation, heart disease, prevention and treatment of overweight and obesity, whole food nutrition and dietary supplement use for disease prevention, essential  fatty acids, fish oil supplementation, lifestyle changes for improved health and mental performance.

“Omega-3 fatty acids are essential for disease prevention and increased quality of life. Aside from their benefit on the heart, brain, and other areas of the body you can’t “feel” on a daily basis, they also help with joint fluidity and pain reduction, which are very tangible issues. The benefits received from obtaining adequate levels of omega-3 fats go on forever, and I believe they should be as “mainstream” as a simple multivitamin.” —Christopher Mohr, PhD, RD

Mohr Results

About Dr. Christopher Mohr

Dr. Christopher Mohr, PhD RD is a nutrition spokesperson and consultant to a number of media outlets and corporations including the The Dairy Council, Clif Bar, Subway, Cardioviva and Nordic Naturals. He is a consulting Sports Nutritionist for the Cincinnati Bengals and is also the Sports Nutritionist for Under Armour’s Training Council. Through his company Mohr Results, Inc., he works with all types of individuals from soccer moms to collegiate and professional athletes.

He is on the Advisory Board for Men’s Fitness Magazine and has written over 500 articles for consumer publications, such as Men’s Fitness, Weight Watchers, Men’s Health and Fitness, to name a few. Dr. Mohr has Bachelor and Master of Science degrees in Nutrition from The Pennsylvania State University and University of Massachusetts, respectively. He earned his PhD in exercise physiology from the University of Pittsburgh and is a Registered Dietitian. To contact Chris, email him at

Nordic Naturals


142 – Stress, Anxiety and Insomnia – My Interview with Dr. Michael Murray

Everyone has stress. Even happy events are stressful. It is even more challenging if one has anxiety and/or insomnia. It is difficult to be happy and healthy if one is overburdened with stress. If you are anxious and don’t sleep well it is difficult for your body to recharge and remain energetic. There are powerful natural therapies and nutritional supplements that can provide profound benefit

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141 – Boosting Your Brain Power – My Interview with Dr. Thomas Shea

Clinical nutritional science has shown conclusively that supplements of specific nutrients can improve both structure and function of our brains,. Brain cells have been shown to be very receptive to certain nutrients. A brain that is well nourished will always do better than one that is nutrient deprived.

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140 – The Clinical Benefits of Korean Ginseng – My Interview with Gregg Noll

Ginseng is known as the world’s most powerful adaptogenic herb. It is also known as the “King of Herbs”. An adaptogenic herb is an herb that assists the body to adapt and adjust to maintain balance and optimal health. Ginseng is considered one of the wonder drugs of nature.

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139 – Omega-3 and Mental Health Research – My Interview with Capt. Joseph Hibbeln, MD

In this interview Dr. Hibbeln will describe some of his research and the important implications for mental health. His research at the time of this interview was to determine if omega-3 fatty acids can reduce suicide behaviors. He also discusses the role of omega-3 for depression and their importance to pregnant and nursing mothers as well as their children.

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138 – The Powerful Potential of Probiotics – My Interview with Natasha Trenev

I ate my first yogurt in 1971 and it happened to be Continental yogurt which was created by Natasha Trenev’s father. I took acidophilus on my first trip to Mexico around that same time to aid my digestive health while traveling. So over 50 years ago I began to appreciate the importance of digestive bacteria.

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137 – Natural Relief for Migraine Headaches – My Interview with Dr. Raj Aggarwal, MD

Doctors and researchers are discovering that nutrition is a viable way to reduce headaches, reduce severity and frequency and potentially lead to reduction or elimination of the need for medications. In this interview with Dr. Raj Aggarwal, we will discuss the cause of migraines and what you can do. Dr. Aggarwal discusses the 10 things you should do to best manage your headaches.

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136 – Overcoming Iron Deficiency Anemia – My Interview with Dr. Erin Stokes, ND

Many years ago, I discovered Blood Builder by MegaFood. This is an amazing supplement. It is the perfect supplement for women struggling with iron deficiency anemia. First of all it works seemingly much better than ferrous sulfate. Women feel much better when taking Blood Builder. It does not upset the stomach or cause constipation.

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135 – My Interview with Daniel Fabricant – CEO, Natural Products Association

I think the heading of this podcast sounds intriguing considering the decades long animosity between the FDA and the natural products industry. Dr. Daniel Fabricant holds the unique position of being involved with FDA regulation of nutritional supplement manufacturers to becoming the Executive Director and CEO of the nation’s only trade association for natural products.

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